Generic name: Albenza (albendazole)
Group affiliation: Anthelmintic and antiparasitic medicine.
Description of the active ingredient.
Albendazole. Dosage form: suspension for oral administration, pills, chewable pills, coated pills.
-worming agent, functioning in mono-and multi invasions. Selectively inhibits the polymerization of beta-tubulin work brakes the microtubular group of cells of the intestinal canal of worms, upholds glucose utilization, blocking the movement of secretory granules and other organelles in the muscle cells of nematodes, causing their death. It is signally efficient against the larval types of cestodes – Echinococcus granulosus and Taenia solium, nematodes – Strongyloides stercolatis.
Indications: Neurocysticercosis, caused past the larval form of Taenia solium (pork tapeworm).  Liver hydatid infection, lung and peritoneum  infections, caused by Echinococcus granulosus (larval type of the dog tapeworm). Nematodothes: ascariasis, trichuriasis, hookworm disease, enterobiasis, strongyloidiasis, opisthorchiasis, giardiasis, microsporidiosis. Conflicting helminthiasis.
Contraindications: Hypersensitivity, pregnancy, lactation, early (up to 6 years – security is not defined). Suppression of bone marrow hematopoiesis, liver failure, cirrhosis of the liver, the pathology of the retina.
On the part of the digestive scheme: stomach aching, nausea, vomiting, increased work of liver transaminaz. From the nervous system: bother, dizziness, predicament in portraying their symptoms.
On the blood: lakopenia, granulozitopenia, agranulozitos, thrombocytopenia, pancytopenia. Allergic reactions: skin rashes, itching of the skin.
Other: hyperthermia, increased ad, the kidneys, alopecia, crucial renal failure.
Overdose. Treatment: symptomatic washed appetite, activated carbon.
Dosage and superintendence: Favoured, after a go too far, do not converse pills, washed down with water. Daily dose – 0.4 g (at a time), for children – 6 mg / kg. The use of laxative drugs and a special diet is required. Children under 2 years – sagacity cysticercosis: 15 mg / kg / age because of 8 days, if predestined, repeat. Hookworm condition, Helminthiasis: 0.2 g once, if obligatory, replicate after 3 weeks. Strongyloidiasis and cestodiasis: 0.2 1 g once everyday for 3 days, if necessary, duplicate after 3 weeks. Children older than 2 years and adults – sagacity cysticercosis: 0.4 g 2 times an hour on 8-30 days. Ascariasis, trichuriasis, and hookworm condition enterobiasis – 0.4 g once, if necessary, repeat after 3 weeks. Giardiasis: 0.4 1 g a single time daily in spite of 3 days. Strongyloidiasis and cestodiasis: 0.41 g once day after day on 3 days, if needed, repeat after 3 weeks.
Cautions: It is demanded cessation of therapy in the advance of leukopenia. When neurocysticercosis involving the eye before treatment is important to look at the retina (the danger of exacerbating its pathology). Women of reproductive mature at baseline examine is performed not pregnant. During therapy required believable contraception. Patients receiving extra doses should be monitored carefully, with constant monitoring of the blood and the liver.
Interaction: Dexamethasone and cimetidine strengthen the concentration of Albenza (albendazole) in the blood.
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